Characteristics of cases with colorectal adenomas and controls
Cases (%)
(n=224)
Controls (%)
(n=230)
P*
Sex
Male
Female
159 (71.0)
65 (29.0)
160 (69.6)
70 (30.4)
0.74
Age (years)
50-59
60-69
70-75
77 (34.4)
116 (51.8)
31 (13.8)
58 (25.2)
135 (58.7)
37 (16.1)
0.11
Body mass index (kg/m2)
<20.0
20.0-24.9
25.0-
27 (12.1)
134 (59.8)
63 (28.1)
29 (12.6)
158 (68.7)
43 (18.7)
0.06
Cigarette smoking (pack-years)
0
1-20
>20
70 (31.2)
38 (17.0)
116 (51.8)
124 (53.9)
38 (16.5)
68 (29.6)
0.001
Drinking status
Never
Ever
Moderate drinkers (<30ml/d)
heavy drinkers (30ml/d-)
79 (35.3)
145 (64.7)
83 (37.0)
62 (27.7)
104 (45.2)
126 (54.8)
71 (30.9)
55 (23.9)
0.09
Exercise
Yes
No
140 (62.5)
84 (37.5)
134 (58.3)
96 (41.7)
0.36
Multivitamin consumption
Current
Occasional
Never
53 (23.7)
15 (6.7)
156 (69.6)
45 (19.6)
16 (6.9)
169 (73.5)
0.57
Family history of colorectal adenomas and cancer
No
Yes
189 (84.4)
35 (15.6)
212 (92.2)
18 (7.8)
0.01
* Examined by t-test or Chi-square test.
Table2.
Genotype distributions of ADH2 and ALDH2 polymorphisms
Cases
Controls
Model 1
Model 2
OR
95%CI
OR
95%CI
ADH2
His/His
His/Arg
Arg/Arg
128
78
18
154
67
9
1.00
1.37
2.45
Reference
0.91-2.05
1.06-5.66
1.00
1.41
2.40
Reference
0.92-2.18
1.00-5.78
ALDH2
Glu/Glu
Glu/Lys
Lys/Lys
142
70
12
140
74
16
1.00
0.93
0.81
Reference
0.62-1.39
0.36-1.75
1.00
0.93
0.83
Reference
0.61-1.42
0.36-1.93
ALDH2 and ADH2
Glu/Glu and His/His
Glu/Glu and Arg+
Lys+ and His/His
Lys+ and Arg+
84
58
44
38
94
48
62
26
1.00
1.32
0.79
1.56
Reference
0.81-2.16
0.49-1.29
0.92-2.61
1.00
1.38
0.78
1.62
Reference
0.82-2.33
0.46-1.30
0.94-2.81
Model 1 adjusted for sex and age;
Model 2 adjusted for sex, age, BMI, smoking status, drinking status, exercise, multivitamin consumption and family history of colorectal adenomas or cancers.
Table 3.
Genotype distributions of ADH2/ALDH2 according to drinking status and their ORs and 95% CIs for colorectal adenomas
ALDH2 Glu/Glu
ALDH2 Lys+
ADH2 His/His
ADH2 Arg+
ADH2 His/His
ADH2 Arg+
ORs(95%CIs) for colorectal adenomas stratified by drinking levels
ORs adjusted for sex, age, BMI, smoking status, drinking status, exercise, multivitamin consumption and family history of colorectal adenomas or cancers.
