P-3-06-10
HYALURANAN (ORTHOVISC) INJECTIONS IN OSTEOARTHRITIS VICTIMS
G. Demirel, N.Kesiktas,: Istanbul Physical Medicine & Rehab. Centre, Istanbul, Turkey
Purpose: The purpose of our study is evaluation of efficacy and side effects in the treatment of sodium hyaluranate (NH) in osteoarthritis patients.
Methods: 50 patients aged between 60-68 years (mean 62,7) matched. 25 of them were injected three times, weekly 15mg/ml (2ml Orthovisc) sodium hyaluronan. And second group were taken oral naproksen sodium (1000mg/day) for three weeks. Clinical evaluations were performed using WOMAC pain index, range of motion (ROM) tests, knee swelling measurements, distance of 50 feets walking time, for X-Rays Kellegren-Lawrence Index were used.
Results: Intraarticuler rejected group had a significant healing of WOMAC pain index, knee ROM tests and walking time than the second group, (p<0.05). Knee measurements and X-Rays haven't significant change, (p<.05). Follow up studies still continue until 6 months.
Conclusion: For clinical benefit, NH may be used in knee osteoarthritis.
P-3-06-11
The effect of vitamin K (Menaquinon-4) on osteoblasts; possible inducer of transcription factor
Ikuko Takasaki-1), Isao Kitajima-2), Ikuro Maruyama-2), Nobuyuki Tanaka-1)
1)-Dept. of Rehabilitation Medicine 2)-Dept. of Laboratory Medicine, Kagoshima University, Kagoshima, Japan
Abstract: Recently, prevention and treatment of osteoporosis are an urgent problem also in rehabilitation medicine. Vitamin K is expected as a novel effective medicine for any type of osteoporosis because of its dual effects on bone remodeling. One of them is the enhancing effect on post-translational gamma-carboxylation of bone Gla protein that is regarded as essential for calcification of osteoblast and bone matrix, another is suppress effect on prostaglandin E2 synthesis and osteoblast formation that induce bone resorption. But it is unclear if vitamin K has any effects on the intracellular signal transduction.
In this study, we performed electrophoretic mobility gel shift assay for detection of DNA binding capacity of some transcription factors.
Result: In murine osteoblast cell line MC3T3E1, vitamin K induced the DNA binding capacity of the transcription factor Nuclear factor kappa B and AP-1 in a biphasic manner. As there are some reports about possible receptor of vitamin K, our finding supports them and suggests gamma-carboxylation independent pathway of vitamin K effects.
