P-2-01-39
METHYLPHENIDATE IMPROVES THE TRAINING ADAPTABILITY OF SEVERE BRAIN DAMAGED PATIENTS, BUT IT PRESENTS ONLY TRANSIENT EFFECTS TO THEIR FUNCTIONAL STATUS
Ichiro Sayama, Eriko Yokoyama, Hideya Miya, and Tomiyoshi Chida
(The Rehabilitation & Psychiatric Medicine Center-AKITA, Akita, Japan)
Abstract: Methylphenidate, a potent amphetamine-like CNS stimulant, facilitates the functional recovery of patients with severe brain damages, such as traumatic brain injury (Plenger PM et al, 1996). In the pre- and post-medication, the effect of this agent along with rehabilitation was investigated by neurological, and by the FDG-PET or the IMP-SPECT studies. Subjects were; a 13-year-old school boy, whose CNS damaged extensively by brain hypoxia, a 33-year-old man with extensive left hemisphere injury due to repeated subarcnoid hemorrhages, a 52-year-old woman with the right large hemispheric damages due to ischemic stroke. During the rehabilitation, the agent was administered 20-30mg per-orally, and all of them showed improvement in consciousness and vigilance, thereby becoming more adaptive to the training. These effects were definitely verified with serial PET/SPECT studies, and their functional levels were upgraded for the moment. These conditions, however, sometimes fluctuated, and ultimately had no visible changes. Methylphenidate has the enhancing effects to such cases, and may be effective when patients are at an unexpected standstill. But Our results indicated, this drug per se could not maintain the improved function, as well as its metabolic effect continuously.
P-2-01-40
ROLE OF SIMPLIFIED STEROTACTIC ASPIRATION THERAPY IN IMPROVEMENT OF MOTOR FUNCTION IN HYPERTENSIVE CEREBRAL HEMORRHAGE
Gao Qian, Zhen Hua and Xia Xugang (Department of Rehabilitaion Medicine, Southwest Hospital Chongqing, 630038, the People's Republic of China)
Abstract: To explore the role of the simplified sterotactic aspiration therapy in improvement of motor function in hypertensive cerebral hemorrhage, 21 patients were treated with medical conservative therapy in combination with the simplified sterotactic aspiration therapy and other 21 patients treated only with the conservative one to serve as the control. Then the Fugl-Meyer Motor Function Assessment was applied to evaluate the improvement of motor function of all the patients. The maul findings were as follows:
1. The difference of the function of the upper extremity between the therapeutic groups and the control was not significant either at the admission or in one month after treatment (P>0.05);
2. The difference of the function of the lower extremity between the two groups was not significant at the admission (P>0.05) whereas the difference in "associated movement, normal reflection, coordination/speed" of the lower extremity between the two groups was significant in one month after the treatment (P<0.05);
These findings suggest that the simplified sterotactic aspiration therapy in combination with the medical conservative therapy is better than the conservative one alone in the improvement of the motor function of the lower extremity in patients with hypertensive cerebral hemorrhage.
