F-2-02-02
FINDINGS OF MAGNETIC RESONANCE IMAGE IN THE RISK INFANTS FOR DEVELOPMENTAL DISTURBANCE
Toyoko Kanda (1-St. Joseph Hospital for handicapped, Kyoto, Japan), Katumi Hayakawa, (2-Kyoto City Hospital), Yuriko Yamori-1, Ruriko Ando-1, Mariko Yuge-1
Purpose: IS to know whether the findings of Magnetic Resonance Image (MRI) correlate with the prognosis of the risk babies for developmental disturbance or not by the prospective study.
Method: 124 risk babies were checked MRI early after starting therapy. All of them were diagnosed risk for the developmentally disturbed in between 1990 and 1995 and were trained by the neurodevelopmental physical therapy of Vojta method in infant age. They were followed afterwards till the prognosis was clear. The MRI findings were compared with the prognosis.
Result: They developed into 21 cerebral palsy (11 spastic diplegia cases), 13 mentally retarded, 18 mentally or physically borderline cases and mentally and physically normal 72 cases. The MRI findings were normal in 63 cases (50.8%). Characteristic findings for cerebral palsy were bilateral cerebral porencephaly and high intensity at globus pallidus in T2 weighted images. Eight cases showed Periventricular Leucomalacia (PVL) which is called typical findings of cerebral palsy, and among them four developed cerebral palsy, two mentally retarded and two borderline. Findings of PVL in spstic diplegic cases appeared after seven months of age. 47 cases showed other atypical findings as ventricular dilatation, cortical atrophy, delayed myelination, thin corpus callosum and periventricular high intensity area in T2 weighted image, and among them 18 cases developed into cerebral palsy, seven mentally retarded, five borderline and 25 normal.
Conclusion: The result shows not the lack of specificity of MRI findings but that the cerebral constitution is under development during early infancy and full of plasticity.
F-2-02-03
BRAIN MRI FINDINGS IN CIIILDREN WITH DEVELOPMENTAL MOTOR DELAY
Jemg Lim Moon, Kang Sae Yoon, Yang Seung Han (The Catholic University of Korea, School of Medicine, Seoul, Korea)
Purpose: This study was planned to evaluate the clinical significance of MRI (Magnetic Resonance Imaging) findings in assessment of the children with developmental motor delay or pathology.
Method: Brain MRI was performed in 34 children with developmental motor delay or motor pathology. Their ages ranged from 4 months to 4 years 5 months (mean 12.9 months). Besides brain MRI, evaluation consisted of patients' history and physical examination. MRI findings were divided into 4 groups to analyze the relationship between MRI findings and motor delay. Mean±standard deviation (S.D.) of motor quotient(M.Q.) were obtained in each group.
Result: 1. Mean±S.D. of motor quotient in each group were 63.6±6.8 in group 1 cases showing normal myelination without associated abnormality and white matter pathology, 29.5±19.4 in group 2 (cases showing normal myelination with associated abnormality or white matter pathology), 35.7±19.9 in group 3 (cases showing delayed myelination with or without associated abnormality and white matter pathology), under 10 in group 4 (cases showing myelination disorder such as leukodystrophy). In group 3 with delayed myelination, motor age corresponded to the age estimated by myelination on MRI in 7 out of 9 cases.
Conclusion: These data would be helpful for assessing the children with motor delay or pathology.
