F-1-05-08
EXERCISE AND ENERGY METABOLISM IN LIVER AND KIDNEY
Taku Harada and Tokutaro Sato (Tohoku University, Sendai, Japan)
Abstract: Changes in energy metabolism of liver and kidney were studied in Wistar rats, which were forced to run on treadmill at speed of 30 m/min for 30 minutes. The blood samples and the tissues were obtained within 5 minutes after secession of exercise.
Levels of glucose, lactate and pyruvate in blood from aorta were higher in fed state than in fasted state. That of glucose was decreased, and those of lactate, pyruvate and free fatty acid were increased by exercise in both of fasted and fed states.
Energy charge of liver was higher in fed state than in fasted state, and decrease in total adenine nucleotisdes contents of liver by exercise was much smaller also in fed state. Different effect of exercise on energy metabolism of liver by food intake may be due to blood flow, which was maintained at higher level even after exercise in fed state and decreased to very low level by exercise in fasted state.
On the contrary, total adenine nucleotide content in kidney was not changed by exercise in fasted state, and decreased in fed state. Supply of free fatty acid and pyruvate from the peripheral tissues and uptake of them by kidney were pronounced in fasted state. This may be the reason why energy metabolism in kidney did not deteriorate by exercise in fasted state.
F-1-05-09
THE INFLUENCE OF PHYSICAL EXERCISE ON MACROPHAGE FUNCTIONS IN THE AGED MICE
Pei TANG, Yucai YAO, Baohui ZHANG (Beijing Medical University, P.R.China)
Abstract: This study was designed to research the influence of physical exercise on nonspecific immune system in the aged. We examined the functions of tile peritoneal macrophage of the aged C57BL/6 mice (the swimming-trained and no-trained groups). The functions of the peritoneal macrophage in the young mice were also studied. Phagocytic activity and tumor-cytostatic activity of the peritoneal macrophage in the aged no-trained mice were lower than that in the young group. Interleukin-1 production, phagocytic activity and tumor-cytostatlc activity of the peritoneal macrophage in the trained aged mice were all higher than those in the aged no-trained group (p<0.001). The results showed that moderate exercise training may promote the macrophage functions in the aged.
