Spontaneous resistant strain and Selection by Drugs

　

・INH: 3.5 x 10^-6

・SM: 3.8 x 10^-6

・RFP: 3.1 x 10^-6

・EB: 0.5 x 10^-4

　

・Non-cavitary TB has 10² to 10⁴ bacilli, whereas cavities ca. 10⁷ to 10⁹ bacilli.

　

Causes of Drug Resistance

　

・Monotherapy or inadequate regimen

・Irregular drug taking

・Poor patient management

・Poor programme management

-DR is a Man-made Disaster.

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