F-4-05-06
IRIDIAN MARKERS IN PROGNOSIS OF CORONARY HEART DISEASE
Alex V. Klemenov (Medical Academy, Nizhny Novgorod, Russia)
The role of hereditary factors in atherogenesis justifies the use of some genetic markers for prognostication of coronary heart disease (CHD). As a similar marker we can consider the peculiarities of iris of eye.
In order to investigate possibilities of iridobiomicroscopy in prediction of CHD the analysis of peculiarities of iris in 250 pts with confirmed diagnosis was performed.
During the iridoscopy the frequency (67,6%) and localization of main iris changes were studied: 2.40-3, 8.40-9.40 for the right iris and 2.40-3.20, 8.20-9.40 for the left one. Association between the iridian markers and the risk of CHD was proved by HLA- antigen linkage study in 132 pts with typical iris signs.
In conclusion, the results of the study showed, that subjects with typical iris changes are in a higher risk of developing CHD.
F-4-05-07
EFFECTS OF EXERCISE TRAINING IN PATIENTS ON CONTINUOUS AMBULATORY PERITONEAL DIALYSIS (CAPD): A CONTROLLED STUDY
Leonard S.W. Li, C.Y. Lo, M.L. Chan, W.K Lo (Tung Wah Hospital, The University of Hong Kong, Hong Kong)
Purpose:This study evaluated the effects of a 12-week exercise program on CAPD patients on the exercise tolerance, blood biochemistry, blood pressure(BP) control, cardiac function and Quality of Life.
Method: 13 CAPD patients underwent three 1-hr. training sessions each week using treadmill, bike and arm ergometers. 7 CAPD patients matched with age, sex and duration of dialysis acted as controls.
Result: The mean VO2max of the exercisers increased by 16.2% after training (pre- and post-exercise 17.2±5.2 vs 20.0±6.1 ml/kg/min, p=0.001). There was no significant change in the following parameters after exercise: serum urea, creatinine, albumin, hematocrit, total cholesterol, left ventricular diastolic/systolic diameters and ejection fraction. A rising trend of HDL was observed (pre- and post-exercise: 0.86±0.28 vs 1.04±0.35 mmol/L, p=0.06). Ambulatory BP monitoring showed a significant rise in the daytime systolic BP in the exercisers (pre- and post-exercise: 142±26 vs 157±22mmHg, p=0.01) but no significant changes could be found in the ambulatory daytime diastolic BP, nocturnal BP and resting BP. The quality of life, as measured by KDQOL-TM, revealed significant improvement in the mean scores on" burden of kidney disease" and "physical functioning". Only 2 hypotensive episodes were reported in 2 patients during exercise. No significant difference could be found in the pre- and post-study parameters in the controls.
Conclusion: This study showed that exercise training could be safely carried out in CAPD patients and could improve their physical capacity as well as quality of life.
