NEUROCHEMICAL STUDIES OF EXPERIMENTAL SPINAL CORD COMPRESSION INJURY
S. Sarai, Y. Nagata, K. Fujita, & N. Dohi* (Fujita Health University, Aichi, Japan; *Hiroshima Prefectural College of Health and Welfare, Hiroshima, Japan)
We investigated temporal alterations of the enzymic activities of cytochrome c oxidase (CO), lactate dehydrogenase (LDH), and supcroxiside dismutase (SOD) which are related to energy production metabolism in the rat spinal cord tissue after the application of compression injury. A pressure clip of 120 g was set extradurally on the C-8 level spinal cord for 5 minutes 1, 3, 6, and 24 hours after the application of compression.
The enzymic activity of CO in the mitochondriai inner membrane decreased to nearly a half level of the initial value at the injured site of the tissue within 1 hour after the application of compression, and stayed at the low level until 24 hours after the application. The Activity of LDH, a marker enzyme for anaerobic glycolysis, continued to increase in the caudal part of the clipped spinal cord, reaching twice the initial value after 24 hours. The activity of SOD, an antioxidant enzyme to scavenge cytotoxic free oxygen radicals, showed a phasic rise in the caudal portion of the tissue 3 hour after the clip application. These biochemical changes in the spinal cord following the clip compression injury were initialed at a very early stage after the compression, especially in the caudal part of the spinal cord. Antioxidant agents effective for recovery from an injury shall be administered as early as possible after receiving an injury in order to minimize the negative effect of the injury.
Management of Heterotopic Ossification in Spinal Cord Injury Patients
Gulcin Demirel, Nur Kesiktas;, Hurriyet Yilmaz,: Istanbul Physical Med. & Rehab. Centre, Istanbul, Turkey
Purpose: To prevent of heterotopic ossification's prolonging effect to the rehabilitation, we design this study.
Methods: In this study, we evaluated 40 SCI patients with HO who matched with etiology, neurologic levels, type of lesion, delay in admission, spasticity, pressure ulcers, X-Rays, alkaline phosphotase (AP) and ESR. 20 of SCI patients took disodiumetidronat (EDT=Didronat) 10mg/kg/day & physical therapy for 8 weeks, control group took physical therapy. Following criterias are swelling (cm), pain (VAS), local temperature, body temperature, range of motion (ROM) limitation, biochemical analysis (Ca, P, ALP, ESR, WBC, Total protein, ALT, AST), X-Rays (evaluated with Nollen & Slooff grading system).
Results: ALP values were slightly reduced in the EDT group, (p 0.05). ALP is not changed in second group. Both groups' X-Rays were same for initial therapy. ROM healed with EDT, (p 0.01) and FIM scores elevated in EDT group.
Conclusion: It may be helpful use of EDT in SCI patients for a better survey.