F-3-19-06
EFFECTS OF CALCITRIOL (ROCALTROL) IN THE TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS
Bettin Durmaz, Kazim Capaci, Mustafa Baris, Belkls Colak, Aynur Tez, Ferda Erer
Ege University, IZMIR, TURKEY
0.5 mcg once a day of calcitriol was administered to 50 osteoporotic women for two years. Clinical and laboratory assessment were done with 6 months interval. Bone mineral density (BMD) was measured (DEXA) at initially, 12 and 24 months. Conventional radiographic evaluation also were done. Calcium intake was restricted to 800-1000 mg/day. BMDs were statistically significant increase between the measurements initial and after treatment. In conclusion, 0.5 mcg per day or calcitriol with restricted calcium intake regimen may be considered safe and effective in patients with postmenopausal osteoporosis.
F-3-19-07
A STUDY ON OSTEOPOROSIS IN STROKE PATIENTS USING BONE MINERAL DENSITY (BMD) AND BIOCHEMICAL MARKERS
Tetsuo IKAI, Kenshaku TEI, Chiko KIMURA, Kotaro TAKATA (Tokyo Metropolitan Rehabilitation Hospital, Tokyo, Japan) Kyozo YONEMOTO (Dep. of Rehabilitation Medicine, Jikei University School of Medicine, Tokyo, Japan)
Osteoporosis is reported as a complication in hemiplegic patients. Hip fracture is frequently seen in hemiplegic patients and becomes a serious problem in rehabilitation. The purpose of this study is to evaluate the osteoporosis in the hemiplegic patients using BMD and biochemical markers.
[Subjects & Methods] 169 hemiplegic patients, within 6 months after CVA, were included in this study. We measured the BMD in the neck of the femur by DXA and assessed the biochemical makers on admission. The ratio of the affected side to the unaffected side was calculated for the BMD. In 78 of the 169 patients, the BMD was measured again after 3 months of rehabilitation.
[Results] The ratio of the BMD decreased in proportion to the time course and was lower in the female patients than in the male patients. The biochemical markers of bone absorption in the patients indicated high levels. The patients, who could not achieve walking after 3 months of rehabilitation, showed a decrease in the BMD in the unaffected side.
[Conclusion] This study showed that bone absorption increased in the hemiplegic patients within 6 months of onset, and there was a difference of decrease in the BMD between male and female patients. Our results suggested that walking was important to keeping bone mineral density in the unaffected side.
