F-2-17-08
EFFECTS OF PHYSICAL THERAPY ON IMMUNOLOGICAL PARAMETERS AND CYTOKINES IN PATIENTS WITH CEREBROVASCULAR DISEASES
Hitoshi Kurabayashi, Kazuo Kubota, Izumi Machida Division of Rehabilitation, Kusatsu Branch Hospital, Gunma University Hospital, Gunma, Japan
[Purpose] To evaluate immune function and cytokines during 2-month physical therapy in patients with cerebrovascular diseases.
[Methods] The lymphocyte subsets (CD3, 4 and 8), lymphocyte responses to phytohemaggulutinin (PHA) and concanavalin A (Con A), natural killer (NK) cell activity, antibody-dependent cellular cytotoxicity (ADCC) activity, and serum levels of cytokines (IL-1β, 2, 2R, and 6) were examined in 22 patients (14 males and 8 females; 68.1±9.9 years) with hemiplegia 2 and 10 weeks after the onset of cerebrovascular diseases who received a conventional rehabilitation program in our hospital between 1992 and 1995. The patients with infection or disturbance of consciousness were not included in this study.
[Results] The ratio of CD4+/CD8+ cells was significantly increased after the 2-month rehabilitation program. The lymphocyte responses to Con A and PHA, ADCC activity and IL-2R were increased, while no significant changes were observed in CD3+ cells, NK cell activity and serum levels of IL-1β, 2 and 6.
[Conclusion] It is suggested that physical therapy may have some effects on the immune system, especially T cell function, and on the cytokine networks.
F-2-17-09
STUDY OF PREMOTOR TIME IN HEMIPLEGICS
M. Suzuki, E. Saitoh, M. Baba, T. Tanaka, M. Suzuki, & N. Fukaya (Fujita Health University, Aichi, Japan)
A patient with a cerebral lesion often develops problems relating to ADL performance. Reaction time can reflect the severity of brain damage and the degree of slowness in performance might be measured by delay in reaction time.
Although many hemiplegic patients are treated in the field of rehabilitation medicine, only a few studies on the patients' reaction time have been conducted.
In this study we measured the auditory reaction time in the upper extremities on the sound side of hemiplegics. More specifically, we examined if the side of cerebral lesion influences the reaction time, and if delay in reaction time relates to clinical manifestations of hemiplegics.
Results: The group of patients with right hemispheric lesion (left hemiplegia) showed a tendency to have more delay in reaction time than those with a left hemispheric lesion. No significant relation was observed between the any particular impairments and delay in the reaction time.
