Antibiotics (including synthetic antibacterials) should be administered for at least 72 hours.When no symotomatic improvement is obtained after 72 hours, the antibiotic should be reolaced by another one.When symotomatic imorovement is obtained after 72 hours of administration the antibiotic should be continued for an additional 72 hours before withdrawal.More than two antibiotic must not be used concomitantly unless otherwise directed by a health care orofessional.
Penicillins cure the infections listed as indications for these drugs in Table 2 (page) by killing the pathogenic organisms.
Indications: Specified in Table 2. Drug ?B is first-line therapy for syphilis.
Dosage: ?@250 mg (1 tablet) 3-4 times daily. ?A250 - 500 mg (1-2 tablets) 4-5 times daily. ?B400,000 U (2 tablets) 2-4 times daily. The same dosage is recommended for the syphilis treatment
Precautions: 1. Prior to treatment, each patient should be asked in detail about a history of drug hypersensitivity (e.g., penicillin shock) and a predisposition to allergic reactions (rash and urticaria) in order to confirm the safety of administering penicillin. These antibiotics must not be administered to those who have a history of penicillin shock.
2. Use of these antibiotics should be discontinued immediately when the patient has any allergic symptoms, e.g., malaise, oral discomfort, a desire to defecate, rash, urticaria, and itching.
3. When penicillins are contraindicated, a tetracycline or an antibiotic of another class should be administered and the response should be monitored.
4. When anorexia or diarrhea occurs, stomachics and/or drugs for regulating intestinal function may be used concomitantly.
5. Penicillins should not be taken together with acidic beverages, e.g., fruit juice.
6. Long-term use of penicillins is only allowed if directed by a health care professional, because their chronic administration may induce bacterial substitution.
Storage: ?@&?AIn a moisture-proof container at room temperature. ?BAt room temperature. Expiry date (time interval after production):?@&?A3 years. ?B5 years.
Tetracyclines
?@Minomycin (Minocycline HCI tablets 100 mg)
?AAchromycin V (Tetracycline HCI capsules 250 mg)
?BVibramycin (Doxycycline HCI tablets 100 mg)
Tetracyclines cure the infections listed as indications for these drugs in Table 2 (P.33) by killing the pathogenic organisms.
Indications: Specified in Table 2.
Dosage: ?@A loading dose of 100-200 mg (1-2 tablets) followed by 100 mg (1 tablet) every 12 to 24 hours.?A250 mg (1 capsule) 4 times daily. ?B100 mg (1 tablet) twice on day 1 and 100 mg (1 tablet) once daily from day 2 onward.
Precautions: 1. Like penicillins, tetracyclines should only be used after confirming the safety in individual patients. These antibiotics must not be administered to those who have a history of hypersensitivity to any tetracycline.
2. Concomitant use of calcium and iron supplements and stomachics which contain magnesium or aluminum should be avoided, because these drugs inhibit the absorption of tetracyclines and reduce their efficacy. Milk must not be taken together with any tetracycline for the same reason.
3. When anorexia, nausea, vomiting, abdominal pain, diarrhea or any other gastrointestinal symptoms occur, a stomachic and/or a drug for controlling intestinal function may be used concomitantly.
4. Consultation with a health care professional is needed when a tetracycline is to be administered on a long-term basis.
Storage:?@&?AProtected from light at room temperature. ?BAt room temperature. Expiry date: ?@&?B3 years. ?A4years.
