(*) If there is resistance to amikacin, kanamycin, and streptomycin, capreomycin is a good alternative. Injectable agents are usually continued for 4 to 6 months if toxicity does not intervene. All the injectable drugs may be given daily (or twice or thrice weekly) and may be administered intravenously or intramuscularly.
(**) Potential agents from which to choose: ethionide, cycloserine, PAS or amoxicillin-clavulanate; clarithromycin, and rifabutin are unlikely to be active.
(+) FQN = fluoroquinolone; in descending order of activity versus M. tuberculosis are sparfloxacin, levofloxacin, ofloxacin, and ciprofloxacin. Sparfloxacin is problematic due to 10% risk of photosensitization.
